GEDEV SEMINARs

05.11.2024 12:30 – 13:30

Presenter: Prof Jorge Ferrer
Centre for Genomic Regulation, CIBERDEM, Barcelona. Imperial College London.

Title: “A cell-specific transcription and splicing hierarchy that is disrupted in human diabetes.”

Summary:
Both gene transcription and RNA splicing networks are pivotal for shaping cell-specific gene expression, yet how these two layers are interconnected remains poorly understood. We have studied beta-cells carrying mutations in HNF1A – a gene central to both monogenic and polygenic diabetes, which encodes the transcription factor hepatocyte nuclear factor-1alpha. Our work showed how HNF1A controls cell-type specific expression by coordinating a regulatory hierarchy that impacts both beta-cell transcription and RNA splicing. Our findings also suggest that this regulatory axis is altered in human type 2 diabetes, and contributed to beta-cell dysfunction. Finally, I will describe efforts to enhance HNF1A in b-cells as a potential therapeutic avenue.

Lieu

Bâtiment: CMU

Auditoire Renold (B01.2426.a)

entrée libre